Modulation of Molecular Fingerprinting in Pediatric Sepsis
Phoenix Children's Hospital
Summary
The goal of this study is to demonstrate the sensitivity and specificity of detecting circulating micro RNA (miRNA) biomarkers in pediatric septic patients. It will also follow expression and modulation of levels in response to therapy in comparison to current biomarkers.
Description
This study will aid in the evaluation of determining the accuracy of these miRNAs in pediatric patients and help in establishing pilot data for additional studies in the future. The testing will include blood samples, urine samples and buccal swabs from patients who meet eligibility at 5 time points to analyze biomarkers. Study participants will receive standard of care with antimicrobials and any additional appropriate cardiovascular or respiratory support per the clinical team. The samples will collected and stored at -80 until analysis can be performed. In addition to, during the course of…
Eligibility
- Age range
- 1–18 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 1 through 18 years * Patients admitted to the PICU with concerns for sepsis or those developing sepsis during their admission to the hospital. * Patients must be enrolled int he study from arrival time tot he ED up to 24 hours from the time of initiation of antibiotic therapy for treatment of sepsis or septic shock. * Signed informed consent. Exclusion Criteria: * Patients \<1 year of age and greater than 18 years of age.
Interventions
- ProceduremiRNA in Sepsis
miRNA in Sepsis
Locations (2)
- Phoenix Children's HospitalPhoenix, Arizona
- Phoenix Children's HospitalPhoenix, Arizona