Molecular Autopsy for Sudden Cardiovascular Death
Scripps Translational Science Institute
Summary
This study seeks to incorporate genetic testing into the postmortem examination of cases of sudden unexplained death.
Description
This study seeks to incorporate genetic testing into the postmortem examination of cases of sudden unexplained death, initially in San Diego County with plans to expand nationally and internationally as funding allows. Genetic testing of the index subjects and their parents (or other biological family members if parents are not available) will be assessed for potential heritable causes of sudden death. By combining the wide catchment base of the San Diego Medical Examiner's Office, sequencing expertise of SD-based collaborators, computing power of the San Diego Supercomputer Center and in-hous…
Eligibility
- Age range
- Up to 45 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Index case age between birth - 45 years * Clinical presentation of sudden / unexplained death (believed to be cardiac in nature OR secondary to a massive unprovoked pulmonary embolism with no prior diagnosis of prothrombotic disease) Exclusion Criteria: * Premature death secondary to murder, suicide or external causal event * Premature death thought secondary to known chronic comorbid medical condition * Premature death thought secondary to end-organ failure (kidney, liver, lung) other than heart * Previously diagnosed with hypertrophic cardiomyopathy (HCM) * Prior myo…
Location
- Scripps Translational Science InstituteLa Jolla, California