Tumor Genomic Profiling: A Personalized Medicine Approach
Stanford University
Summary
This research trial studies using genomic profiling to recommend anticancer treatment to patients with cancer that has spread beyond the original site of the tumor (metastatic cancer). Genomic profiling studies the deoxyribonucleic acid (DNA) of a tumor to detect genetic changes or abnormalities. This information can then be used to recommend treatments that may be more likely to result in a beneficial response. It is not yet known whether genomic profiling will detect abnormalities that can be used to make treatment recommendations and whether treatment based on genomic profiling is more effective than standard treatment.
Description
PRIMARY OBJECTIVES: I. Assess the feasibility of integrating tumor genomic profiling in the adult oncology clinic at the Stanford Cancer Institute. SECONDARY OBJECTIVES: I. Determine the percentage of tumors that harbor "actionable" genomic changes. II. Explore effects of individual molecular profiling including the percent of time that profiling changes the treatment. III. Determine the number of cases in which a genomically identified targeted therapy is available. IV. Determine the clinical benefit of genomic based therapy, as defined by: response rate (according to Response Evaluation…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Understand and provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization prior to initiation of any study-specific procedures * Have a diagnosis of metastatic, incurable cancer and have progressed on at least one line of systemic therapy OR a cancer with no standard 1st-line systemic therapy shown to prolong survival (or where a clinical trial recommended as the 1st-line option) * Measurable disease (RECIST 1.1) * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 * In the opinion of the investigator,…
Interventions
- Geneticmutation analysis
Correlative studies
- Othercytology specimen collection procedure
Correlative studies
- Otherlaboratory biomarker analysis
Correlative studies
Location
- Stanford UniversityPalo Alto, California