Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
Massachusetts General Hospital
Summary
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
Description
* This study is being done to study effects of chemotherapy (cancer treatment) on the brain and cognition (thinking). "Chemo-brain" is a term sometimes used to refer to effects of chemotherapy on the brain and cognition (thinking). * This study is being done to test for "chemo-brain" in older adults with breast cancer treated with chemotherapy, and to identify people who are most likely to be affected. The investigators will look at thinking abilities and brain images before and after chemotherapy to see if it can help identify people at risk for cognitive side effects of the treatment, and to…
Eligibility
- Age range
- 60+ years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Breast cancer patients treated with chemotherapy- Group 1 (experimental group) * Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study * New diagnosis histologically confirmed invasive breast cancer * Treatment plan to include chemotherapy * Female subjects age ≥ 60 years. * Life expectancy ≥ 1 year * Karnofsky Performance Score (KPS) ≥ 80 * Ability to understand and the willingness to sign a written informed consent document. * Non-treated breast cancer patien…
Interventions
- OtherCognitive, functional and subjective assessments
Cognitive and functional assessments
- DeviceMRI
Magnetic Resonance Imaging (MRI) Scan
- RadiationPET Scan
Positron Emission Tomography (PET) Scan
Locations (2)
- Massachusetts General HospitalBoston, Massachusetts
- Massachusetts General Hospital/North Shore Cancer CenterSalem, Massachusetts