Peripheral Blood Flow Responses to Electromagnetic Energy
University of Alabama at Birmingham
Summary
This study evaluates 670 nm energy in the form of red light to stimulate blood flow changes in healthy adults. All participants will receive red light to their leg. They will also receive a continuous infusion of Definity (octafluoropropane) ultrasound contrast.
Description
670 nm energy in the form of red light dilates isolated blood vessels. This study seeks to measure vessel dilation in human subjects exposed to this energy at different irradiance intensities (25 milliwatts (mW)/cm2 and 75 mW/cm2). The intent of this protocol is to measure blood flow in the gastrocnemius muscle before and after exposure to 670 nm light energy. This protocol will be performed in healthy subjects, who do not meet exclusion criteria. The study consists of one visit. Blood flow measurement will be performed using contrast enhanced ultrasound, a method by which ultrasound contrast…
Eligibility
- Age range
- 18–59 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Participants will be healthy subjects over the age of 18. * Men and women will be recruited for participation. * All ethnicities will be included in this study. Exclusion Criteria: Exclusionary criteria include: * age under 18 years and those over 60 years of age, * those who are unable to understand the consent process, * those who cannot read or speak English, * a history of cancer, * peripheral artery disease, * diabetes mellitus, * active pregnancy, * hypersensitivity to perflutren contrast agents, * pulmonary hypertension, * chronic kidney disease, * active tobac…
Interventions
- Device670 nm light
670 nm light emitting diode will be placed 1 cm above the gastrocnemius muscle. The diode will not be in direct contact with the skin. Subjects will be exposed to 75 mW/cm2.
- Drugoctafluropropane
Octofluoropropane will be administered as a continuous infusion prior to the initiation of 670 nm light in order to measure skeletal muscle blood flow.
Location
- Medical College of WisconsinMilwaukee, Wisconsin