Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging
Massachusetts General Hospital
Summary
The aim of this pilot study is to assess the ability of a new polarization sensitive optical coherence tomography system to obtain high-quality images of retinal birefringence.
Description
Glaucoma is the second leading cause of blindness in the world. The current clinical standard-of-care procedure to diagnose glaucoma is visual field testing with disc photography. Visual field testing is subjective both in the patient's feedback and the physician's interpretation of this feedback, and disc photography requires a physician's subjective interpretation. As a result, it is estimated that current methods can diagnose glaucoma only after 40% of the nerve fiber layer (NFL) has been lost. Since glaucoma leads to significant changes in both NFL thickness and NFL optical birefringence,…
Eligibility
- Age range
- 18–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Male or female subjects between the ages of 18-85 years 2. Healthy normal subjects with no significant eye disease, except for mild cataracts 3. Subjects with clear enough cornea or clear enough media to permit imaging 4. Subjects with refractive error between -5.00 sph to +5.00 sph Exclusion Criteria: 1. Subjects who have occludable narrow angles (without a patent peripheral iridotomy) or any other ocular or systemic pathology, which precludes safe dilation 2. Subjects whose eyes have been dilated for over 6 hours will not be eligible for imaging. 3. Subjects who do…
Interventions
- DevicePolarization-Sensitive OFDI
OCT Imaging of the eye
Location
- Massachusetts General HospitalBoston, Massachusetts