M.D. Anderson Cancer Center
This phase II trial studies how well donor cytotoxic T lymphocytes work in treating patients with malignancies with BK and/or JC virus. Cytotoxic T lymphocytes are made from donated blood cells that are grown in the laboratory and are designed to kill viruses that can cause infections in transplant patients and may be an effective treatment in patients with malignancies with BK and/or JC virus.
PRIMARY OBJECTIVE: I. To assess the efficacy, feasibility and safety of administering most closely human leukocyte antigen (HLA)-matched BK specific cytotoxic T lymphocyte (CTL) lines (BK-CTLs) generated by ex vivo expansion to mediate antiviral activity in patients with any type of malignancies, and/or HIV/AIDs, and/or history of solid organ transplant with BK and JC infections., SECONDARY OBJECTIVE: I. To assess the persistence of the administered BK-CTLs generated by ex vivo expansion in immunocompromised patients, patients with any type of malignancies, or HIV/AIDs, and/or history of so…
Inclusion Criteria: * Patients ≥ 2 years. * English and non-English speaking patients are eligible. * Immunocompromised patients including but not limited to those with any type of malignancy, HIV/AIDS, or history of solid organ transplant * Non-immunocompromised patients with PML/JC virus encephalitis * Microscopic or greater hematuria urine or blood PCR positive for BK virus * Biopsy proven BK nephritis and urine or blood PCR positive for BK virus disease and/or polyomavirus. * Definite or probable PML/JC viral encephalitis (see Appendix C) * JC end-organ disease * Receiving \> 6 mg / day o…
Given IV
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