A Multicenter Prospective Study Evaluating Outcomes of Endoscopic Eradication Therapy in Patients With Barrett's Esophagus Associated Neoplasia: The TREAT-BE (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) Consortium
University of Colorado, Denver
Summary
A prospective outcomes study in patients with and esophageal cancer (EAC) and Barrett's esophagus (BE) associated neoplasia being evaluated for endoscopic eradication therapy (EET).
Description
Patients will be enrolled in this study at the participating centers when evaluated in gastro-intestinal (GI) clinics and endoscopy suites. Initial evaluation of patients will include collection of data on demographics, assessment of risk factors such as smoking, metabolic syndrome, family history and detailed medication history, and past surgical history. All patients will be complete questionnaires regarding Gastroesophageal Reflux Disease (GERD) symptoms, GERD related quality of life (QOL) and overall health related QOL. Details of all previous endoscopic and surgical evaluation along with…
Eligibility
- Age range
- 18–100 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Patients with Barrett's related neoplasia and dysplasia. Patients with esophageal cancer Exclusion Criteria: * Patients with squamous cell carcinoma
Interventions
- ProcedureEndoscopic eradication therapies (EET)
Endoscopic eradication therapies (EET) includes endoscopic mucosal resection (EMR), which describes the process by which the area most likely to harbor highest grade of dysplasia/neoplasia is removed; radiofrequency ablation (RFA), which describes the process by which Barrett's segments are removed via burning/ablation; and cryotherapy.
- ProcedureEsophagectomy
The esophagus is surgically removed
- DrugChemotherapy
Chemical substances are used to treat cancer
- RadiationRadiation
Cancer cells are destroyed by radiation therapy.
Locations (4)
- UCLA Medical CenterLos Angeles, California
- Moffitt Cancer CenterTampa, Florida
- Northwestern Memorial HospitalChicago, Illinois
- Washington UniversitySt Louis, Missouri