Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans

Yale University

Summary

The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.

Eligibility

Age range: 18–55 years
Sex: All
Healthy volunteers: Yes

Detailed criteria

Inclusion Criteria: * at least one lifetime exposure to cannabis * good physical and mental health Exclusion Criteria: * cannabis naive individuals * major current or recent stressors * taking estrogen supplements or oral contraceptive pills (for women)

Interventions

Drug
THC
Active THC (0.015mg/kg) administered over 10 minutes
Drug
Placebo
Control: small amount of alcohol (quarter teaspoon), with no THC over 10 minutes

Location

Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine
West Haven, Connecticut
christina.luddy@yale.edu 203-932-5711