Mayo Clinic
The study goal is to assess the effect of senescent cell clearance on senescence burden, physical ability or frailty, and adipose tissue-derived mesenchymal stem cell (MSC) functionality in patients with chronic kidney disease (CKD).
The proposed studies will examine cellular senescence and the effect of senolytic therapy on senescent cell burden, frailty, and adipose-derived mesenchymal stem cell function in individuals with diabetic chronic kidney disease.
Inclusion Criteria: 1. Age 40-80 years 2. Chronic kidney disease estimated glomerular filtration rate (eGFR) 15-45 ml/min/1.73m2 3. Diabetes mellitus and taking diabetes medications Exclusion Criteria: 1. Concomitant glomerulonephritis, 2. Nephrotic syndrome, 3. Solid organ transplantation, 4. Autosomal dominant or recessive polycystic kidney disease, 5. Known renovascular disease, 6. Pregnancy, 7. Active immunosuppression therapy, 8. Hemoglobin A1c≥10% at screening, 9. History of active substance abuse (including alcohol) within the past 2 years, 10. Current alcohol abuse (\>3 alcoholic be…
Dasatinib - take one 100 mg tablet by mouth once daily for 3 consecutive days.
Quercetin - take four 250 mg capsules daily (total 1000 mg daily) for 3 consecutive days.
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