David Reardon, MD
This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : * Abemaciclib (arm is currently closed to accrual) * Temozolomide (temodar) * Neratinib (arm is currently closed to accrual) * CC115 (arm is currently closed to accrual) * QBS10072S
This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational drug to learn whether the study drug works in treating a specific disease. "Investigational" means that the drug is being studied. In this research study, the investigators are looking to compare the effects, good and bad, of the standard of care with the three investigational agent sub-studies Abemaciclib, Neratinib, CC115, QBS10072S to help people with Glioblastoma including the specific molecular changes in the genes and proteins. The FDA has approved Temozolo…
Inclusion Criteria: * Participants must have histologically confirmed intracranial glioblastoma or gliosarcoma following maximum surgical resection. Tumors primarily localized in the infratentorial compartment will be excluded. * Participants may have had prior surgery for glioblastoma or gliosarcoma but no systemic or radiation therapy. * Age ≥ 18 years. * Karnofsky performance status ≥60 * Participants must have normal organ and marrow function as defined below: * Leukocytes ≥3,000/mL * Absolute neutrophil count ≥1,500/mL * Platelets ≥100,000/mL * Hemoglobin ≥ 9g/dl * Total bilir…
Temzolomide capsules
Neratinib tablets
QBS10072S administered intravenously
Abemaciclib tablets
CC-115 tablets