Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
University of Pittsburgh
Summary
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
Description
Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes, Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis, Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric Sensors, Social Network Questionnaire, Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, and the COVID19 Response Surveys.
Eligibility
- Age range
- 7+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Inclusion criteria for MS patients include: 1. Age 7 years or older 2. Willing and able to provide consent (for \>=18 years) or assent with permission from at least one of the child's parents (for \<18 years) 3. Diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease * For healthy controls: 1. Age 7 years or older 2. Willing and able to provide consent (for \>=18 years) or assent with permissi…
Location
- University of PittsburghPittsburgh, Pennsylvania