Peter Merkel
Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
This study employs a multi-center approach to evaluate cutaneous vasculitis across several forms of idiopathic vasculitis. Patients with cutaneous manifestations of vasculitis will be evaluated by teams of primary vasculitis care providers and Dermatologists in order to facilitate optimal selection of patients and sampling of lesions. A punch skin biopsy at a site of active vasculitis will be the source of material for histopathologic and transcriptomic evaluation. The histopathology of cutaneous vasculitis will be characterized using a standardized approach.
Inclusion Criteria: * Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis * Have a suspected or confirmed diagnosis of: * Cryoglobulinemic vasculitis (CV) * Drug-induced vasculitis * Eosinophilic granulomatosis with polyangiitis (EGPA) * IgA vasculitis * Isolated cutaneous vasculitis * Granulomatosis with polyangiitis (GPA) * Microscopic polyangiitis (MPA) * Polyarteritis nodosa (PAN) * Urticarial vasculitis * Be willing and able to provide written informed consent (or ass…