Patient-Centered NeuroRehabilitation
University of Michigan
Summary
As individuals grow older, a number of factors can reduce our cognitive (or thinking) abilities such as "normal" aging, neurodegenerative diseases, and cardiovascular disease. This study will evaluate whether cognitive rehabilitation and transcranial electrical stimulation (TES) can improve cognitive abilities. Cognitive rehabilitation refers to methods that are used to improve tasks people have trouble doing in everyday life. Transcranial electrical stimulation uses small amounts of electricity to try to alter brain functioning. These approaches may help improve cognitive abilities like attention, learning, memory, finding words, and problem solving as well as everyday functioning. The goal of this study is to identify how to best use these methods, either alone or in combination.
Description
The primary objective of this study is to evaluate the feasibility of a neurorehabilitation treatment tailored to individual patient needs, with the ultimate goal of maximizing cognitive and real-world functioning for older adults with cognitive aging, mild cognitive impairment (MCI), neurodegenerative, or other neurological diseases/conditions. Transcranial electrical stimulation (TES) is a non-invasive, neurorehabilitation procedure in which a weak electric current is passed between electrodes that are placed on the scalp with the intention of modulating excitability of the underlying brain…
Eligibility
- Age range
- 50+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Individuals who have reported cognitive dysfunction and cognitively intact participants. 2. Participants will be age 50 or older Exclusion Criteria: 1. A history of epilepsy 2. Sensory or motor impairments that limit the ability to take part in the study 3. Current alcohol or drug abuse/dependence 4. Those who are currently pregnant or may become pregnant during the duration of the study (if there is a question of pregnancy, pregnancy tests will be available for participants at no charge) Those who are being evaluated for TES methodology will also be excluded for 1)…
Interventions
- DeviceActive tDCS
Participants will receive active tDCS at up to 4mA per electrode for up to 40 minutes for up to 260 sessions.
- DeviceSham tDCS
Participants will receive sham tDCS for up to 260 sessions
- BehavioralCognitively based intervention
Participants may receive a cognitively based intervention that targets the particular cognitive and/or functional abilities of interest. This includes methods of cognitive training, cognitive remediation, and cognitive rehabilitation for up to 260 sessions
- DeviceActive tACS
Participants will receive active transcranial alternating current stimulation at up to 4mA per electrode for up to 40 minutes for up to 260 sessions
- DeviceSham tACS
Participants will receive sham transcranial alternating current stimulation for up to 260 sessions
- DeviceActive tRNS
Location
- University of Michigan - Department of PsychiatryAnn Arbor, Michigan