Genetic Basis of Melanocytic Nevi
University of California, Davis
Summary
The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion criteria: * Male or female subjects that are 18 years or older * Subjects with melanocytic nevi\\ Exclusion criteria: * Patients less than 18 years of age * Patients without melanocytic nevi * Patients with a bleeding disorder or are taking anticoagulation medication
Interventions
- OtherCollecting Nevi
Will be collecting Nevi and completing a DNA analysis, no intervention will be made.
Location
- University of California-Davis, Department of DermatologySacramento, California