Evaluating the Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion in Hip Fracture Patients
Gregory M Georgiadis MD
Summary
Tranexamic Acid (TXA) is an antifibrolytic medication used in total hip and knee arthroplasty to reduce the need for intraoperative and postoperative blood transfusions. Limited research is available on its use in hip fracture patients. We hypothesize that the use of TXA preoperatively, perioperatively, and postoperatively will decrease blood loss and need for blood transfusion postoperatively.
Eligibility
- Age range
- 60+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Over the age of 60 years * Hip fracture requiring surgical intervention * Signs consent and agrees to participate Exclusion Criteria: * Under the age of 60 * Does not sign consent or refuses participation * Known hypersensitivity to tranexamic acid * Multiple acute fractures * Creatinine clearance \<30 * History of seizures * Active hormone therapy * History of coagulation abnormality * History of deep vein thrombosis (DVT) or pulmonary embolism (PE) within the last year or history or recurrent DVT/PE * Myocardial infarction (MI) and/or stents within the past year * Hi…
Interventions
- DrugTranexamic Acid (TXA)
Tranexamic acid is an antifibrinolytic used to control bleeding
- DrugSaline solution
Saline solution is used as the placebo comparator
Location
- ProMedica Toledo HospitalToledo, Ohio