Investigating Metabolic Characteristics of Intracranial Malignancy In Vivo Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)
University of Texas Southwestern Medical Center
Summary
This is a non-randomized, purely observational, feasibility study to detect metabolic changes in patients with brain malignancy using a novel hyperpolarized \[1-13C\]pyruvate MRSI.
Description
The aim of this pilot study is to test the hypothesis that patients with brain malignancy present altered \[1-13C\]lactate and 13C-bicarbonate production from infused hyperpolarized \[1-13C\]pyruvate in tumor as compared to in normal-appearing brain regions. To achieve this aim investigators will assess metabolic phenotype in cancer patients with brain tumors (n = 20). Total target enrollment will be set at 25 subjects to account for attrition and screening failures. During each imaging session, following localization of the tumor in brain, tissue characteristics and morphological changes wil…
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Definitive diagnosis of brain tumors by imaging which demonstrates all kinds of brain malignancy, including glioma, meningioma, and brain metastases prior to any chemotherapy or radiation treatment. * 18-70 years of age * Ability to understand and the willingness to sign a written informed consent. * All races and ethnicities will be included; subjects must be able to read and speak the English language. Once the protocol is established, Spanish-speaking participants will be included. * Women of child-bearing potential must agree to use adequate contraception (hormonal o…
Interventions
- DrugHyperpolarized 13C-Pyruvate
Hyperpolarized 13C-pyruvate IV bolus followed by brain MRSI.
- DrugGadolinium
Brain MRI performed with and without gadolinium-based contrast.
Location
- UT Southwestern Medical CenterDallas, Texas