Interventions for Postoperative Delirium: Biomarker-3
University of Wisconsin, Madison
Summary
The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.
Eligibility
- Age range
- 60+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Cohort 1: Age ≥65 years * Cohort 2: Age ≥60 years * Anticipated length of hospital stay of at least 2 days after surgery that occurs under general or neuraxial anesthesia * Written Informed Consent for potential participation prior to surgery Exclusion Criteria: * Contraindication to EEG * Unable or unwilling to attend the follow-up appointments * Documented history of dementia * Deemed incapable of providing consent by surgical team * Residing in a nursing home * Undergoing intracranial surgery * Unable to complete neurocognitive testing due to language, vision or hea…
Interventions
- ProcedureHigh Density-Electroencephalogram
EEG is a safe non-invasive technology without complications that may be used to help diagnose delirium
- ProcedureMagnetic Resonance Imaging
MRI scan of brain
- ProcedureBlood specimen collection
Blood will be collected from participants
- Diagnostic TestPupillometry
A pupillometer is a device that measures the size of the pupils.
Location
- University of Wisconsin-MadisonMadison, Wisconsin