M.D. Anderson Cancer Center
This trial studies how well dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) works in diagnosing osteoradionecrosis in patients with head and neck cancer that is primary, has come back, or has spread to other places in the body who are undergoing radiation therapy. DCE-MRI may help doctors to predict osteoradionecrosis in patient with head and neck cancer undergoing radiation therapy.
PRIMARY OBJECTIVES: I. To determine whether DCE-MRI following external beam radiation therapy (EBRT) can be used to reliably predict osteoradionecrosis (ORN). SECONDARY OBJECTIVES: I. Define dose-response relationships between DCE-MRI derived imaging biomarkers and subsequent development of ORN. II. Evaluate the use of DCE-MRI parameters to monitor ORN response to treatment. III. Assess the use of DCE-MRI parameters in preoperative planning in advanced ORN subjects. IV. Develop MRI-based biomarkers inclusive predictive models for development of radiotherapy-attributable tissue injury wit…
Inclusion Criteria: * Willing and able to provide informed consent * Patients must have histologic evidence of malignant neoplasm that may have been obtained from the primary tumor or metastatic lymph node * Receipt of external beam radiation therapy (EBRT) with curative intent, with or without concomitant chemotherapy * Good performance status (Eastern Cooperative Oncology Group \[ECOG\] score 0-2) * Willing to comply with all study procedures; and * Willing to participate for the duration of the study * COHORT 1 (LONGITUDINAL) GROUP 1 (PRE-RADIATION): Subjects who are currently undergoing o…
Undergo DCE-MRI
Ancillary studies
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