Milton S. Hershey Medical Center
Determine the utility of biomarkers measured in blood and body fluid (stool, saliva, tracheal aspirate) when combined with clinical data, for predicting sepsis phenotypes that are associated with poor clinical outcomes. We hypothesize that resistin is a biomarker which provides critical prognostic information when used in conjunction with standard clinical data, in patients with sepsis and septic shock.
Day 1 Sample Collection: 20ml of blood for chemical and genetic biomarker analysis. ≤1ml of saliva, stool, and tracheal aspirate for inflammatory marker analysis. Quadratus lumborum muscle size measurement and CT abdomen correlation. If not part of routine care, additional blood tests for cell differential, procalcitonin, and inflammatory markers. Electronic Medical Records (EMR) Data: APACHE II and SOFA severity scores. Demographics, vital signs, inflammatory markers, organ dysfunction markers, and various blood chemistry values. Days 2-3 Daily Documentation: Record the most abnormal value…
Inclusion Criteria: 1. Adults (age ≥ 18 ) 2. gender: male or female 3. Cognitively intact or impaired patients, given that sepsis may cause a certain degree of cognitive dysfunction in patients. All patients in the control group (no sepsis) will be cognitively intact 4. Clinical suspicion for sepsis (except for control/comparison group for whom infection is NOT a current concern) Exclusion Criteria: 1. Patients with hematologic malignancies 2. Pregnant women 3. Patient/surrogate is not fluent in English and no translation services are available 4. Long-term immunosuppressive therapy 5. Pris…
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