Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
University of Colorado, Denver
Summary
The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology. To do so, the investigators want to determine how obesity and the metabolic syndrome relate to metabolism in bronchial airway epithelial cells and the nasal epithelium.
Description
This is a cross sectional pilot study comparing specific metabolic pathways in bronchial airway epithelial cells and the nasal epithelium across the following patient groups: 1. Obese (Body Mass Index (BMI) ≥ 30) asthmatics without metabolic syndrome, 2. Obese asthmatics with metabolic syndrome, 3. Obese non-asthmatics, and 4. Non - obese (lean \> 18 \<= 25, Overweight (OW) \> 25 - \<30) asthmatics. Participants in these groups will be matched by gender, age and asthma severity. To be enrolled, participants must be non-current smokers and be controlled. After meeting screening criteria, part…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: For ALL Groups 1. Adequate completion of informed consent process with written documentation 2. Male and female patients, ≥ 18 - 65 years old 3. Smoking history \<10 pack years and no smoking in the last year \*\*Subjects can be included in the study if they are on blood pressure treatment and are on a diet control/exercise only treatment of diabetes. 4. Specific to Asthma Groups i. From all racial/ethnic backgrounds with a diagnosis of asthma based on physician diagnosis for \>6 months 1. Specific to Metabolic Syndrome Group. Metabolic syndrome diagnosis based on h…
Interventions
- ProcedureBronchoscopy and Nasal Epithelium Brush Sampling
After meeting screening criteria, participants will undergo further evaluation to determine whether or not inclusion and exclusion criteria are met. Participants will undergo a baseline evaluation, lung function testing and a subsequent bronchoscopy and nasal epithelial brush sampling in those that meet study enrollment.
Location
- University of ColoradoAurora, Colorado