Cortical Spreading Depolarization After Severe Traumatic Brain Injury
Hennepin County Medical Center, Minneapolis
Summary
Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention.
Description
The goal of this study is to improve our understanding of cortical spreading depolarizations (CSDs) as a mechanism of secondary injury in severe traumatic brain injury (TBI). The primary obstacles to advancing treatment of TBI are its heterogeneity in terms of cause, severity, pathophysiology and the paucity of therapeutic targets. At the current time, there is no intervention to reverse or restore the function of brain tissue damaged or lost during the initial traumatic insult; therefore the therapeutic focus is centered on minimizing secondary insults that result in expansion of the initial…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patient recommended to undergo craniectomy or craniotomy for the treatment of acute TBI Exclusion Criteria: * Wound determined to be contaminated * Decompression is performed only in the posterior fossa * Known systemic infection * Pregnancy
Interventions
- Diagnostic TestContinuous electrocorticography post severe traumatic brain injury requiring neurosurgical intervention
Continuous electrocorticography via subdural electrode strips for 1 to 3 weeks in the neuro intensive care unit following traumatic brain injury
Location
- Hennepn HealthcareMinneapolis, Minnesota