Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
University of Virginia
Summary
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.
Description
Hyperpolarized Xenon-129 MRI has been developed by a number of techniques for imaging the lung that provide information about various aspects of lung function and structure. The main objective of this pilot study is to test and optimize the imaging parameters for a future industry sponsored clinical trial. The goal of the future trial is to determine the concordance between hyperpolarized xenon-129 ventilation MR imaging and nuclear medicine ventilation imaging (Gold Standard). In this study we will test the imaging parameters and techniques. We will directly compare human ventilation lung ima…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subjects must have a diagnosis of COPD * at their clinical baseline on the day of imaging * must be clinically stable in order to participate in the study. * COPD subjects will be categorized according to the GOLD * Current/Former SmokerSubjects * must have a smoking history ≥ 10 pack years Exclusion Criteria: * Dx of asthma * Continuous oxygen use at home * Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging * FEV1 percent predicted less than 25% * Pregnancy or lactation * Claustrophobia, inner ear implants, aneurysm or other s…
Interventions
- DrugHyperpolarized Xenon-129 MRI (Experimental)
MRI ventilation scan of the lung with inhaled contrast agent (hyperpolarized Xenon-129)
- DrugRadioactive Xenon-133 scintigraphy (Active Comparator)
Radioactive ventilation scintigraphy of the lung with inhaled radioactive contrast agent (Xenon-133)
Location
- University of Virginia Health SystemCharlottesville, Virginia