Natural History of Wilson Disease: Registry for Patients With Wilson Disease
Yale University
Summary
The purpose of the registry/repository is to provide a mechanism to store data and specimens to support the conduct of future research about Wilson disease (WD). The overall aim is to determine the optimal testing for diagnosis and parameters for monitoring treatment of WD that will aid product utilization and development.
Description
There are three aims outlined as part of this research study. Aim 1 is to study the natural history of a carefully characterized cohort of patients with WD followed longitudinally at Centers of Excellence for WD in the United States and in the United Kingdom. Aim 2 seeks to evaluate parameters for diagnosis and treatment monitoring for patients on chelation therapy and zinc treatment for their WD. Data gathered in Specific aim 1 will be used for analyzing the components of the diagnostic scores for patients. Aim 3 is intended to determine whether a composite index or a biomarker can be used…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Known diagnosis of WD * Able and willing to provide informed consent for adults (Parental/guardian permission (informed consent) and if appropriate, child assent for participants \<18 (or per local Institutional Review Board (IRB) regulation) Exclusion Criteria: * Diagnosis of WD has been excluded * Unwilling to provide informed consent or assent
Locations (6)
- Yale UniversityNew Haven, Connecticut
- Advent HealthOrlando, Florida
- Baylor College of MedicineHouston, Texas
- Seattle Children's HospitalSeattle, Washington
- Universitätsklinikum HeidelbergHeidelberg
- Royal Surrey Country HospitalGuildford, Surrey