MERIT (Mammography, Early Detection Biomarkers, Risk Assessment, and Imaging Technologies) Cohort
M.D. Anderson Cancer Center
Summary
This study collects mammogram images, blood samples, and clinical information from women undergoing routine screening mammograms. Creating a bank of blood samples and a database of clinical and risk information may be used in future research related to breast cancer, other cancers, and women's health.
Description
PRIMARY OBJECTIVES: I. To establish a longitudinal cohort (n=10,000) of women who undergo routine annual mammography screening with follow-up for at least five years for each study participant or until breast cancer diagnosis. II. To create a repository of blood specimens from the cohort to use for biomarker discovery and validation. III. To create a comprehensive integrated database of imaging, clinical data, health measurements, and questionnaire data on the study participants. OUTLINE: Participants complete questionnaires over 15-25 minutes about personal and family history of cancer,…
Eligibility
- Age range
- 25–80 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Willingness to participate in the study and ability to provide informed consent * Willingness to complete a questionnaire and to provide a blood sample at the initial visit and at follow up annual visits * Undergoing a screening mammogram at participating sites. Subjects undergoing routine annual diagnostic mammograms or CEM as part of a screening study are also eligible. Exclusion Criteria: * Current or recent (within the prior 6 months) history of breast feeding * Personal history of breast cancer (ductal breast carcinoma in situ \[DCIS\] or invasive breast cancer) *…
Interventions
- ProcedureBiospecimen Collection
Undergo collection of blood samples
- ProcedureMammography
Undergo standard of care mammography
- OtherQuestionnaire Administration
Complete questionnaires
Location
- M D Anderson Cancer CenterHouston, Texas