Mayo Clinic
This phase II trial studies the effect of ascorbic acid and combination chemotherapy in treating patients with lymphoma that has come back (recurrent) or does not respond to therapy (refractory), clonal cytopenia of undetermined significance and chronic myelomonocytic leukemia (CMML). Ascorbic acid may make cancer cells more sensitive to chemotherapy. Drugs used in chemotherapy, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ascorbic acid and combination chemotherapy may kill more cancer cells. Arms A, B, C, and D are closed to enrollment.
PRIMARY OBJECTIVES: I. To determine the overall response rate (ORR) at the end of 2 cycles for intravenous (IV) ascorbic acid (AA) added to standard salvage therapy compared to standard salvage therapy plus normal saline in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who have relapsed within the first 24 months of end of their therapy. \[Arms A versus (vs) B\] II. To determine the ORR at the end of 2 cycles of AA plus standard salvage chemotherapy in patients with other types of relapsed/refractory lymphomas not eligible for Arms A/B \[peripheral T-cell lymphoma (P…
Inclusion Criteria: * Age \>= 18 years * Biopsy-proven relapsed or refractory lymphomas; relapsed is defined as a relapse that occurred after having a response to the last therapy that lasted \> 6 months; refractory is no response or relapse within 6 months; previous biopsies \< 6 months prior to treatment on this protocol will be acceptable * NOTE: Arms A/B - relapsed or refractory DLBCL within 24 months from the end of anthracycline-based therapy; no prior salvage therapy; patients can have received radiation therapy as part of initial treatment but not specifically for relapse * NOTE:…
Given IV
Given IV or PO
Given IV or PO
Given IV or PO
Given IV or PO
Given IV or PO
Given IV or PO
Given IV or PO
Correlative studies
Given IV or PO
Given normal saline IV
Ancillary studies
Given IV
Given IV
Undergo blood sample collection
Undergo core needle biopsy
Undergo bone marrow aspiration and biopsy
Undergo bone marrow aspiration and biopsy
Undergo ECHO
Undergo PET/CT
Undergo MRI
Undergo PICC placement
Undergo portacath placement
Undergo PET/CT
Given PO