The Role of Probiotics in Attenuating Inflammation and Improving Gut Health in Obese Adults
Penn State University
Summary
This study evaluates the effects of probiotic consumption on inflammatory outcomes and measures of gut health. Participants will be given yogurt with probiotics for one period and yogurt without probiotics for another, with a break in between. These periods will occur in random order.
Eligibility
- Age range
- 55–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * BMI ≥ to 25 and less than 35 kg/m\^2 * Increased waist circumference (men: ≥ 94 cm, women: ≥ 80 cm) * At least one of the metabolic syndrome criteria- * serum triglycerides: ≥ 150 mg/dL * HDL cholesterol: ≤ 40 mg/dL in men, ≤ 50 mg/dL in women * blood pressure: ≥ 130 mmHg systolic or ≥ 85 mmHg diastolic * fasting plasma glucose ≥ 100 mg/dL Exclusion Criteria: * allergy to dairy * smoking and/or use of tobacco products * systolic blood pressure ≥ 160 mmHg * diastolic blood pressure \> 100 mmHg * fasting glucose ≥ 126 mg/dL * history of myocardial infarction, cardiovascu…
Interventions
- DrugYogurt smoothie with BB-12
During the one month intervention period, the participants will consume one yogurt smoothie with BB-12 daily.
- DrugYogurt smoothie
During the one month control period, the participants will consume one yogurt smoothie daily.
Location
- The Pennsylvania State UniversityUniversity Park, Pennsylvania