Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
Children's Hospital of Philadelphia
Summary
Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of the efficacy or safety of specific anti-seizure medications or overall management strategies. This is a single-center prospective observational study. The investigators aim to: (1) track critically ill patients undergoing clinically indicated EEG monitoring and seizure management to identify risk factors for electrographic seizures, (2) create prediction models guiding EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our current management strategy in terms of safety.
Description
Context: Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of specific medication selections or overall management strategies. The Children's Hospital of Philadelphia (CHOP) has a formal ICU EEG Monitoring Pathway aiming to standardize EEG monitoring and seizure management. This is a single-center pr…
Eligibility
- Age range
- 0–18 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Care in the Children's Hospital of Philadelphia Pediatric ICU. 2. Clinically indicated continuous EEG monitoring. 3. Age \> 1 month to 18 years. Exclusion Criteria: 1. Admitted for Phase 2 (intracranial) EEG monitoring. 2. Intensivist expects to discontinue technological support in the next two days given underlying medical or neurological problems.
Interventions
- OtherClinically indicated EEG monitoring.
Children enrolled in the study will be undergoing clinically indicated EEG monitoring. Some children will undergo clinically indicated electrographic seizure management.
Location
- Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania