Pharmacokinetics of Anesthetics and Analgesics in Children and Adolescent
Chi Dang Hornik
Summary
The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.
Description
This is a research study to find out what the side effects are of certain drugs that are commonly used for pain and to put people to sleep for surgery. The researchers also want to know how the drug is broken down in the body. Participants will be given these drugs as they are prescribed by their regular doctor. As part of the participant's standard of care, doctors will perform tests, ask questions, review medical information and measure vital signs (heart rate, blood pressure, etc). The researchers will collect information that doctors have already written in the medical records. The researc…
Eligibility
- Age range
- 0–17 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. 0 to \<18 years of age at time of enrollment (must see applicable appendix for details as not all appendices enroll across the entire age range) 2. Parent and/or participant (if applicable) is able to understand the consent process and provides informed consent and HIPAA Authorization (if applicable) 3. Participant provides assent as required by the institutional review board (IRB) or research ethics board (REB) 4. Receiving one or more drugs of interest (DOI) per local standard of care 5. Meeting DOI-specific inclusion criteria (See Appendices) Exclusion Criteria: 1.…
Interventions
- DrugKetorolac Tromethamine
IV ketorolac will be given per standard of care, not prescribed for this study
- DrugHydromorphone
IV Hydromorphone will be given per standard of care, not prescribed for this study
- DrugKetamine
IV Ketamine will be given per standard of care, not prescribed for this study
- DrugOxycodone
PO Oxycodone(solution or tablet) will be given per standard of care, not prescribed for this study
- DrugMorphine
IV Morphine will be given per standard of care, not prescribed for this study
Locations (13)
- Lucile Packard Children's HospitalStanford, California
- Children's Hospital ColoradoAurora, Colorado
- Alfred I. DuPont Hospital for ChildrenWilmington, Delaware
- Ann and Robert H. Lurie Childrens Hospital of ChicagoChicago, Illinois
- Cardinal Glennon Children's HospitalSt Louis, Missouri
- Washington University School of MedicineSt Louis, Missouri