Alterations in the Human Microbiome With Commonly Used Topical Medications
University of California, Davis
Summary
The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: 1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. 2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.
Description
The microorganisms present on human skin influence human health and disease. Older methods of studying the skin microbiota, such as culture based techniques, favored bacteria, which readily grew under standard laboratory conditions, compared to current molecular approaches, which have shown a greater diversity of skin microbiota. Human skin is a large organ that contains a wide range of physiological and topographical diversity. Distinct niches exist which predispose certain areas, such as hairy, moist underarms to a different bacterial community from dry, smooth sites, such as forearms. Given…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
The inclusion criteria: • Adults at least 18 years of age. The exclusion criteria: * Individuals with known chronically active skin diseases, including atopic dermatitis, psoriasis, seborrheic dermatitis, other autoimmune and inflammatory skin conditions. * Patients with a history of skin cancer, multiple nevi, or other isolated lesions will not be excluded. * Individuals who have used topical, intravenous, intramuscular, or oral antibiotics within the last 6 months * Individuals with known allergies to any of the study medications. * Individuals younger than 18 years of age. * Adults un…
Interventions
- DrugDesonide 0.05%
Desonide 0.05% ointment topically twice daily for two weeks
- DrugKetoconazole 2%
Ketoconazole 2% cream topically twice daily for two weeks
Location
- University of California, Davis, Department of DermatologySacramento, California