Ischemic Conditioning During Air tRansport Save penUmbral Tissue
Enrique Leira
Summary
The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic stroke due to large vessel occlusion being transported to a thrombectomy capable center by the helicopter.
Description
In this study, 15 subjects presenting to a community hospital with signs and symptoms of ischemic stroke due to large vessel occlusion, transported to a comprehensive stroke center by aircew will receive RLIC using the Doctormate device. The RLIC treatment will consist of 3-5 cycles ( depending on transportation time) of 5 minutes inflations of both blood pressure cuffs simultaneously. Blood pressure will be 200 mm HG with 5 minutes of reperfusion between each inflation. Subjects will be evaluated upon arrival to the comprehensive stroke center and evaluated for side effects. The study will…
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Age ≥18 and ≤ 80 years 2. Suspected acute ischemic stroke with symptoms suggestive of large vessel occlusion (aphasia, agnosia, neglect, visual field cut, and gaze preference). 3. Patient screened for rtPA, and rtPA administered if eligible 4. Subject or legally authorized representative able to provide consent at the time of the assessment 5. NIHSS 6-20 Exclusion Criteria: 1. Any intracranial hemorrhage (parenchymal, subarachnoid, subdural, epidural) on CT scan at the community hospital 2. History of upper or lower extremity ischemia, known subclavian, brachial arter…
Interventions
- DeviceIschemic conditioning device
RLIC will be done using a specialized blood pressure device ( Doctormate) that inflates to 200 mm HG for 5 minutes followed by 5 minutes deflation.
Location
- University of IowaIowa City, Iowa