Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma
Emory University
Summary
This clinical trial evaluates the influenza virus vaccination in evaluating human immune response in patients with lymphoma. Evaluating immune response may increase the understanding of how the immune system changes when patients receive treatment for lymphomas by looking at the antibody levels and the level of the different cells that make up the immune system over time compared to those without lymphoma.
Description
PRIMARY OBJECTIVE: I. To determine the seroprotection and seroconversion rates after influenza or SARS-CoV2 vaccination in patients with lymphoma receiving active treatment or in follow up observation. SECONDARY OBJECTIVES: I. To characterize virus-specific plasmablasts and memory B cells after vaccination in patients with lymphoma receiving active treatment or in follow up observation. II. To investigate the longevity of viral-specific humoral immunity to influenza virus in patients with lymphoma receiving active treatment or in follow up observation. III. To assess the timing and streng…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subjects with a diagnosis of lymphoma falling into the following categories: * B-NHL who have received 1 cycle of chemotherapy * B-NHL in complete remission and within 12 months after completion of chemotherapy * Chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL) receiving ibrutinib for at least 1 month * B-NHL in complete remission for over 12 months * Aggressive peripheral T-cell lymphoma (PTCL) who have received 1 cycle of chemotherapy * Subject capable of providing written or electronic informed consent prior to initiation of any study proced…
Interventions
- BiologicalInactivated Influenza Vaccine
Given seasonal inactivated influenza vaccine IM
Locations (2)
- Emory University Hospital MidtownAtlanta, Georgia
- Emory University Hospital/Winship Cancer InstituteAtlanta, Georgia