University of Texas Southwestern Medical Center
This project is to evaluate sensitivity and specificity of hyperpolarized 13C-pyruvate as imaging agents of altered cerebral glycolysis and mitochondrial dysfunction and assess pyruvate utilization in mitochondria in Traumatic Brain Injury (TBI) patients.
Aim 1: Investigators will quantify changes in \[1-13C\]lactate and H13CO3- labeling following a bolus injection of hyperpolarized \[1-13C\]pyruvate during the time window of secondary injury to assess upregulated glycolysis. Due to heterogeneous presence and severity of damage by TBI, defining the injured brain region can be difficult. Therefore, the metabolite ratio maps (\[product\]/\[pyruvate\]) of TBI patients (n = 5) will be compared with those of healthy-controls (n = 3). Hyperpolarized \[2-13C\]pyruvate will be examined in a separate group of TBI cohorts (n = 5) and healthy controls (…
Inclusion Criteria: TBI Patients * Injury occurred within 30 days * Documented and verified TBI by Glascow coma scal 10-15 and/or Loss of Consciousness \>10 minutes. * Head Computed Tomography at admission. ALL Subjects: * 18 through 60 years of age. * Ability to understand the the willingness to sign a writteninformed consent. * All races and ethnicities will be included; subjects must be able to read and speak either the English or Spanish language. Exclusion Criteria: * Non-traumatic structural brain abnormality identified on head CT. * Metallic foreign bodies on the scalp or cranium…
Bolus injection of study drug
Bolus injection of study drug
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