Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas
Oregon Health and Science University
Summary
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities. 2. Develop OCT metrics for more sensitive detection of keratoconus progression. 3. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.
Eligibility
- Age range
- 14–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: GROUP A: * Keratoconus: 1. CDVA ≥ 20/25 in the better eye; and both of the following in the worse eye 2. Topography characteristic of keratoconus or pellucid marginal degeneration * Contact lens-related corneal warpage: 1. Contact lens use; and 2. Topography irregularities * Dry eye: 1. Symptoms of dry eye documented by Ocular Surface Disease Index (OSDI) questionnaire score ≥ 30; and 2. Topography irregularities 3. Presence of punctate epithelial erosion on exam with surface staining 4. Aqueous deficiency or evaporative dry eye * Epithelial basement me…
Interventions
- DeviceOptical Coherence Tomography
This device will be used to tightly classify corneal irregularities and determine eligibility of candidates from Group A into Groups B \& C.
Location
- Humberto MartinezPortland, Oregon