Pilot Intervention With Near Infrared Stimulation: Revitalizing Cognition in Older Adults and Those With Parkinson Disease
University of Florida
Summary
The current study will test whether age-related cognitive and mood changes in older adults and those will be affected by near infrared (NIR) stimulation. The overall hypothesis, drawn from previous literature, is that exposure to NIR stimulation will have positive effects on brain health and will result in better cognitive and mood performance.
Description
This is a multi-site pilot study of the efficacy of NIR stimulation for enhancing cognition and mood in nondemented older adults. Sites include the University of Florida and University of Arizona. Prior research suggests that NIR exposure may be neuroprotective and increases energy available to neurons. The current study will test whether age-related cognitive and mood changes in older adults will be affected by near infrared (NIR) stimulation. The study team will randomize older adults into treatment groups and evaluate neuroimaging and cognitive outcome measures, before and after a 12-week…
Eligibility
- Age range
- 65–89 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * No evidence of dementia or Mild Cognitive Impairment based on cognitive screening (i.e., Montreal Cognitive Assessment (MoCA) scores within normal limits for age , education, and sex using the NACC Uniform Data Set (UDS) norms or Dementia Rating Scale (DRS-2) scores \<5thile), and age-appropriate delayed Story recall (i.e., WMS-III Logical Memory) and confrontation naming (Boston Naming Test) * Able to provide informed consent and perform cognitive and mood measures on a computer * At least 8th grade education and/or ability to read at 8th grade level * Willingness to be…
Interventions
- DeviceMedx Console System
This intervention delivers near infrared (NIR) light using light emitting diodes applied to the head and via an intranasal applicator for a period of approximately 1.5 hours. A total of 16 sessions take place in the lab over 12 weeks.
- DeviceSham Medx Console System
This intervention uses sham application of near infrared light (NIR) using light emitting diodes applied to the head and via an intranasal applicator for a period of approximately 1.5 hours. A total of 16 sessions take place in the lab over 12 weeks.
- DeviceVielight 810 intranasal stand alone unit
Daily at home intranasal NIR stimulation sessions, 25 minutes in duration, 4 days each week.
- DeviceSham Vielight 810 intranasal stand alone unit
Daily at home intranasal "sham" NIR stimulation sessions, 25 minutes in duration, 4 days each week.
Locations (2)
- University of ArizonaTucson, Arizona
- University of FloridaGainesville, Florida