Vanderbilt University Medical Center
The overall goal of this research is to develop and validate standard operating procedures (SOP) to assess the human pancreas in individuals with type 1 diabetes (T1D) and other forms of diabetes using advanced, quantitative magnetic resonance imaging (MRI) approaches.
This research applies magnetic resonance imaging (MRI) techniques to study the pancreas of individuals with type 1 diabetes (T1D) and other forms of diabetes. Recent studies have demonstrated reduced pancreatic volume is present within months of T1D diagnosis in children, adolescents, and adults, and in non-diabetic individuals expressing islet autoantibodies that portend the development of T1D. As the pancreatic beta cells constitute only 1-2% of the pancreas, the degree of reduction in pancreas volume at disease onset suggests exocrine involvement, challenging the established paradigm of T1D…
Inclusion Criteria: * Subjects at least 8 years of age * Subjects with T1D must be imaged within 100 days of their date of diagnosis * Subjects must be able to read and provide assent/informed written consent Exclusion Criteria: * Subjects with pancreatitis, cystic fibrosis, pancreatic adenocarcinoma, or neuroendocrine tumors * Subjects who have any type of bioimplant activated by mechanical, electronic, or magnetic means because such devices may be displaced or malfunction * Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced * Subjects who are pregna…
subjects lie in an MRI machine (non-contrast) for 30 minutes while we take pictures of their pancreas
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