Modulating Celecoxib Induced Blood Pressure Changes by Timed Administration of Aspirin and the Human Chronobiome
University of Pennsylvania
Summary
To determine whether timed administration of aspirin ameliorates the effects of celecoxib on blood pressure.
Description
Non-steroidal anti-inflammatory drugs (NSAIDs) are a commonly used and effective treatment of inflammatory pain. However, all NSAID have the potential to raise blood pressure (BP), cause the development of new hypertension or exacerbate preexisting hypertension. Strategies to mitigating that risk short of withholding the analgesic are missing. In this proposal, the investigators wish to determine whether timed administration of low dose aspirin can be developed as a low cost intervention with well-defined risk profile to mitigate the blood pressure raise associated with the COX-2 selective NSA…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Men and women greater than 18 years of age 2. Subjects must be in good health based on medical history, physical examination, vital signs, and laboratory tests. In order to ensure sufficient enrollment of subjects in the higher age groups, volunteers with the following conditions may participate in the study: 1. Adequately controlled hypertension, with diastolic blood pressure ≤100 mmHg at screening. 2. Total cholesterol of ≤270 mg/dL 3. Body mass index (BMI) between 18 and 30 kg/m2. 4. Has not used tobacco products, including smoking cessation nicotine-containin…
Interventions
- DrugAspirin 81 mg
timed administration of aspirin in the evening
- DrugCelecoxib 200mg capsule
daily administration of celecoxib
Location
- Institute for Translational Medicine and Therapeutics (ITMAT), University of PennsylvaniaPhiladelphia, Pennsylvania