Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

Boston Children's Hospital

Summary

This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these drugs in this setting.

Eligibility

Age range: 0–17 years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * supported on ECMO * receiving one or a combination of the following drugs dexmedetomidine, fentanyl, midazolam or morphine as part of sedation management Exclusion Criteria: -none

Interventions

Drug
Dexmedetomidine
Administered for sedation management per hospital protocol
Drug
Fentanyl
Administered for sedation management per hospital protocol
Drug
Midazolam
Administered for sedation management per hospital protocol
Drug
Morphine
Administered for sedation management per hospital protocol

Location

Boston Children's Hospital
Boston, Massachusetts