Feasibility of [¹⁸F]-Fluoromisonidazole (FMISO) in Assessment of Malignant Brain Tumors
OHSU Knight Cancer Institute
Summary
This phase II trial studies how well ¹⁸F- fluoromisonidazole (FMISO) works with positron emission tomography (PET)/magnetic resonance imaging (MRI) in assessing participants with malignant (cancerous) brain tumors. FMISO provides information about the oxygen levels in a tumor, which may affect how the tumor behaves. PET/MRI imaging produces images of the brain and how the body functions. FMISO PET/MRI may help investigators see how much oxygen is getting in the brain tumors.
Description
PRIMARY OBJECTIVES: I. Determine the feasibility of obtaining ¹⁸F- fluoromisonidazole (FMISO) PET (hypoxic volume and tumor to blood background values \[T/B\]) and dynamic susceptibility contrast enhanced (DSC) \& diffusion-weighted imaging (DWI) MRI measures in patients with intracranial brain tumors. II. Determine if MRI contrast-enhancement and hypoxic volume are imaging profiles of glioblastoma immunotherapy-mediated pseudoprogression or true progression in a clinical trial. SECONDARY OBJECTIVE: I. Determine the feasibility of baseline and follow-up FMISO PET and MR imaging co-registra…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult patients (greater than 18 years of age) with a known or suspected intracranial tumor. * Able to provide informed written consent and/or acceptable surrogate capable of providing consent on the patient's behalf. * Legally authorized representative (LAR)-signed informed consent and assent obtained for those subjects identified as decisionally impaired * Intracranial lesion known or suspected to be neoplastic greater than 10 mL as assessed by T2/fluid attenuated inversion recovery (FLAIR) MR imaging. * Karnofsky performance score \> 60 or Eastern Cooperative Oncology…
Interventions
- Drug¹⁸F-Fluoromisonidazole
Given IV
- ProcedureComputed Tomography
Undergo PET/CT
- ProcedureMagnetic Resonance Imaging
Undergo PET/MRI or PET/CT
- ProcedurePositron Emission Tomography
Undergo PET/MRI
- ProcedureOxygen Therapy
Receive supplemental oxygen
Location
- OHSU Knight Cancer InstitutePortland, Oregon