Impact of Circadian Misalignment on Energy Balance Regulation
Columbia University
Summary
Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and interoception; supporting a role of sleep and meal misalignment, on energy balance regulation. No study has been done to disentangle the effects of sleep and meal timing on body weight regulation, independent of sleep duration. This study will provide information to guide messaging related to timing of meals and sleep that can be translated to individuals whose sleep follows unconventional times, such as shift workers and those with jetlag and social jetlag.
Description
The proposed study will test whether the misalignment of eating occasions to the sleep period influences health markers. The goal of the proposed study is to determine whether eating out of synchrony with sleep influences risk of chronic diseases. The proposed study has both mechanistic and translational objectives. First, the investigators will test whether eating late in the day will influence energy balance (hormones, energy expenditure, nutritional intakes). Next, they will observe how misaligned meals, relative to aligned meals, influence behavior. Overweight men and women will be recruit…
Eligibility
- Age range
- 20–49 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * All racial and ethnic groups * Body mass index 20-34.9 kg/m2 * Average sleep duration ≥7 hour/night, assessed during 2-week screening period * Eat within 1 hour of awakening at least 5 days/week * Midpoint of sleep at 4 AM or earlier Exclusion Criteria: * \<10 nights of sleep \<7 hour during the 2-week screening period * Daytime napping * Current or past sleep disorder (Sleep Disorders Inventory); Insomnia Severity Index Score \>10 * Current or past psychiatric disorder, including eating disorders and seasonal affective disorder * Any psychological or psychiatric disor…
Interventions
- BehavioralMeal times
Meal times vary based on the arm: aligned or misaligned
Location
- Columbia University Irving Medical CenterNew York, New York