Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers
Dana-Farber Cancer Institute
Summary
This research study is evaluating a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma.
Description
The purpose of this research study is to test a new method for determining the stage and prognosis of patients with malignant pleural mesothelioma. Currently, it is not possible to accurately determine cancer stage prior to surgery or another treatment. This new method may allow doctors to better classify cancer stage and give a better estimate for prognosis prior to surgery or another treatment. In this research study, the investigators would like to use biopsied tissue to study certain characteristics that will help test the new method for determining cancer stage and estimating prognosis.…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * All adult patients with a diagnosis of malignant pleural mesothelioma undergoing * diagnostic pleural biopsy * pleuroscopy * and/or VATS resections * Participants must be 18 years of age or older. Exclusion Criteria: -Any patient who is found to be unsuitable for * surgery, * treatment * diagnosis,
Interventions
- OtherMPT Test
molecular expression tests at the RNA level using approximately 7 or more genes with RTPCR, nanostring or similar platforms
- OtherCLDN15/VIM Test
molecular expression tests at the RNA level using approximately 7 or more genes with RTPCR, nanostring or similar platforms
Location
- Brigham and Women's HospitalBoston, Massachusetts