Y90 Radioembolization Dose Delivery and Radiation Exposure Assessment
University of Tennessee
Summary
The objective of this study is to examine critical aspects of radiation exposure, dose delivery, and systemic yttrium-90 (Y90) exposure related to the infusion of Y90 microspheres for treatment of hepatocellular carcinoma (HCC) and other metastatic liver disease.
Description
Radioembolization using Y90 microspheres is a relatively new therapy option for patients with hepatocellular carcinoma (HCC) or other metastatic disease. This process requires the injection of radioactive beta-emitting spheres to delivery a targeted dose to the lesion resulting in cell death. With this technology comes many questions related to the safety and handling and usage of these products. This study will focus on three key aspects of dose delivery using these products. The first aim will examine radiation exposure to staff that are involved in handling Y90 microspheres. Radiation expo…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * All patients undergoing Y90 radioembolization therapy with SIR-Spheres or TheraSpheres are eligible to participate in this study * Must be able to schedule and tolerate additional PET/CT imaging following therapy * Must be able to tolerate additional blood draws before, during, and after the radioembolization therapy procedure. Exclusion Criteria: * Patients that are not candidates for Y90 radioembolization therapy * Patients that cannot tolerate additional imaging procedures following therapy * Patients that cannot tolerate the additional blood draws required for this…
Interventions
- Diagnostic TestPost therapy PET/CT Imaging
whole-body PET/CT following Y90 radioembolization
Location
- University of Tennessee Medical CenterKnoxville, Tennessee