Three- Versus Five-Fraction Regimens of Stereotactic Body Radiotherapy for Peripheral Early-Stage Non-Small-Cell Lung Cancer: A Prospective Randomized Phase II Study
University of Rochester
Summary
This study's goal is to find out if the kind of side effects people experience from radiation is different depending on the schedule of their radiation treatment. Patients will be randomly assigned to either the 3 Fraction or 5 Fraction schedule of radiation. After patients complete radiation treatment, they will follow up with their radiation oncologist.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Histological confirmation of non-small cell cancer will not be required as primary goal of this phase II trial is to look at toxicity. However, all primary non-small cell lung cancers otherwise of following types are eligible: squamous cell carcinoma, adenocarcinoma, large cell carcinoma, bronchioalveolar cell carcinoma, or non-small cell carcinoma not otherwise specified. * Eligible patients must have appropriate staging studies identifying them as specific subsets of AJCC stage I or II based on only one of the following combinations of TNM staging: * T1, N0, M0 * T2 (≤…
Interventions
- Deviceradiation therapy-3 fractions
Radiation therapy given in a 3 fraction schedule (over 3 days). Total dose is 54 Grays.
- DeviceRadiation therapy-5 fractions
Radiation therapy given in 5 fractions (over 5 days). Total dose is 60 Grays.
Location
- James P. Wilmot Cancer Center at University of Rochester Medical CenterRochester, New York