Imaging and Detection of Micrometer Sized Early Stage Pancreatic Cancer by Using Endoscopic Ultra-High Resolution Optical Coherence Tomography (OCT) Using Resected Pancreatic Specimen, a Pilot Study
Ohio State University Comprehensive Cancer Center
Summary
This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer. Ultra-high resolution optical coherence tomography may help to accurately identify pancreatic cancer in resected pancreatic specimens.
Description
PRIMARY OBJECTIVES: I. To evaluate the using of optical coherence tomography (OCT) to diagnose pancreatic cancer arising in the setting of intraductal papillary mucinous neoplasms (IPMN) using the resected pancreatic specimen. II. To correlate OCT imaging diagnosis with histologic findings in the human pancreatic duct. IPMN is a premalignant lesions arising in the pancreas. Typically, IPMNs are identified incidentally on imaging performed for other reason or related to vague abdominal pain or gastrointestinal complaints. In terms of IPMN, invasive cancer can be found in this setting between…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Immediate surgery cohort: Adult patients with pancreatic cancer or IPMN * Immediate surgery cohort: Informed consent will be obtained * Adult patients undergoing pancreatic resection for a presumed IPMN Exclusion Criteria: * Pregnant
Interventions
- ProcedureOptical Coherence Tomography
Undergo OCT
- ProcedureTherapeutic Conventional Surgery
Undergo resection will be undertaken
- Diagnostic TestLaboratory Evaluation
Labs will be obtained to test for cancer cell derived exosomes
Location
- Ohio State University Comprehensive Cancer CenterColumbus, Ohio