Chicago Alternative Prevention Study for Diverse Populations of High Risk Women
University of Chicago
Summary
This study is aimed to establish a registry of women undergoing intensive surveillance for the early detection of breast cancer in high-risk women.
Eligibility
- Age range
- 25+ years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: \- Known BRCA1 or BRCA2, TP53, PALB2, PTEN, CDH1 and STK11 carrier. Women with pathogenic mutations in any other cancer susceptibility genes are eligible only if they also have a high PRS. OR * With life time risk of 30% or higher, based on Polygenic Risk Score that integrates genetic and non-genetic factors OR * 5-years risk ≥ 6% for women 40-64 OR * 5-years risk ≥ 6% for women 65+ AND breast density C or D AND a lifetime risk \>= 20% (BCSC+PRS LTR or Tyrer-Cuzick LTR) OR * Patients with history of chest wall radiation received before age 35. OR * To promote health equi…
Interventions
- ProcedureMagnetic Resonance Imaging (MRI)
Patients will have MRI scans every 6 months.
Location
- University Of Chicago Medicine Comprehensive Cancer CenterChicago, Illinois