M.D. Anderson Cancer Center
This phase I trial studies the side effects of linear energy transfer (LET) optimized image modulated proton therapy (IMPT) in treating pediatric patients with ependymoma. Radiation therapy such as LET optimized IMPT, uses proton beams to kill tumor cells and shrink tumors without damaging surrounding normal tissues.
PRIMARY OBJECTIVES: I. To evaluate the safety of linear energy transfer (LET) optimized image modulated proton therapy (IMPT) (bio-IMPT) for pediatric patients with ependymoma. SECONDARY OBJECTIVES: I. To utilize advanced multiparametric magnetic resonance (MR) imaging to identify imaging biomarkers of structural and biological changes after proton therapy in pediatric ependymoma patients. II. To compare quantitative image biomarkers in patients treated with bio-IMPT and standard proton therapy using a voxel level analysis. III. To test and evaluate the validity of relative biological eff…
Inclusion Criteria: * Previous pathologic confirmation of ependymoma, World Health Organization (WHO) grade II or III * Disease must be confined to the brain (no evidence of spread on MR imaging of the spine or on staging lumbar puncture) * Patient may not receive chemotherapy concurrent with radiation * Signed informed consent by patient and/or parents or legal guardian * Lansky performance status score of 50 -100 Exclusion Criteria: * Patients with previous radiation therapy to the brain * Ependymoma of the spine * Disseminated ependymoma requiring craniospinal radiation therapy * Pregnan…
Given LET optimized IMPT
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Ancillary studies
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