University of Pittsburgh
This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.
Chronic wounds affect a large fraction of the world population and poses major threat to the public health and economy of the United States affecting 6.5 million patients. It has been estimated that approximately 2% of the population residing in developed countries, will experience at least one chronic wound during their lifetime. Current treatment options for chronic wounds are insufficient due to lack of individual specific genetic information. To improve therapy, an increase in the investigator's understanding of the genetic predisposition of individuals which result in impaired wound heali…
Inclusion Criteria: * Age ≥ 18 years * Willing to comply with protocol instructions, including all study visits and study activities. * Chronic wounds (\> than four weeks since onset) * Clinically diagnosed diabetic or non-diabetic ulcer. * For patients with multiple wounds, the largest wound will be used for the study. Exclusion Criteria: * Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent) * Pregnant females (self-declared) or lactating * Subjects with marked immunodeficiency (HIV/AIDS or immune-suppres…
Not applicable - No Interventions
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