Hypoplasminogenemia: An International RetroSpecTive and PrOspective CohoRt StudY (HISTORY)
Indiana Hemophilia &Thrombosis Center, Inc.
Summary
This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities
Description
The aims of this study are to: 1. Define PLGD natural history in a large cohort of individuals with hypoplasminogenemia and their first-degree family members. 2. Identify factors that correlate with disease expression and severity. 3. Create a specimen biobank for further studies, available to other researchers. The project will be international in scope with two collaborating centers that have created and will collect the subject data and samples. In North/Central/South America, the Indiana Hemophilia \& Thrombosis Center (IHTC) will serve as the primary site while University of Milan will…