Dennis Turner, M.D.
This study involves patients who are already planning to have deep brain stimulation (DBS) surgery to treat the symptoms of severe Parkinson's Disease (PD). The study has two goals: 1. to evaluate the effectiveness of implanting DBS electrodes in the two most common locations for DBS (subthalamic nucleus (STN), and globus pallidus interna (GPi)), instead of just one electrode, on each side of the brain; and 2. to develop an adaptive DBS system using brain signals measured from these two electrodes.
The purpose of this study is a small, first in man, clinical feasibility trial for patients with severe Parkinson's Disease (PD), who are already clinically eligible for deep brain stimulation (DBS) with two goals: 1. to compare efficacy from two common sites of DBS (subthalamic nucleus (STN), and globus pallidus interna (GPi)) through the implantation of dual DBS electrodes on each side of the brain; and 2. to develop a closed loop DBS system using evoked and spontaneous potentials derived from these two electrodes. The study will involve bilateral dual DBS electrode placement in clinically…
Implanted RC+S arm Inclusion / Exclusion Criteria: Inclusion Criteria: * able to give informed consent * diagnosed with Parkinson's Disease and is considered a surgical candidate for DBS * has medication-related side effects from levodopa (i.e., dyskinesias, on-off fluctuations) * has off-on improvement with levodopa of at least 30% * is available for follow-up visits for length of study Exclusion Criteria: * is not safe surgical candidate for DBS * has severe neurological injury or disease other than Parkinson's Disease * has condition requiring repeated MRI scans * has untreated, clinica…
DBS stimulation of STN alone
DBS stimulation of GPi alone
cooperative DBS stimulation of STN and GPi sites
adaptive DBS stimulation of STN and/or GPi sites
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