Research Into Visual Endpoints and RB Health Outcomes After Treatment (RIVERBOAT)
Vanderbilt-Ingram Cancer Center
Summary
This trial studies health outcomes after treatment in patients with retinoblastoma. Gathering health information over time from patients and family members through vision assessments, samples of tissue and saliva, and questionnaires may help doctors learn more about what causes retinoblastoma, identify long-term health outcomes for patients with retinoblastoma, and find out which therapies may be the best for treating retinoblastoma
Description
PRIMARY OBJECTIVES: I. Define acute toxicity, subsequent malignant neoplasm (SMN) risk and visual outcomes in retinoblastoma (RB) survivors and compare patient centered psychosocial and neurocognitive and physical outcomes in survivors with normative data and sibling controls. II. Create the first Clinically-Annotated Patient Tissues to Analyze Gene INteractions to assess biologic correlates of disease and facilitate future research: The RIVERBOAT-CAPTAIN biorepository, including germline deoxyribonucleic acid (DNA) and tumor tissue from patients, with detailed patient, disease and treatment…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- Yes
* Unilateral or bilateral intraocular retinoblastoma * Diagnosis between the ages of 0 - 17.99 years * Diagnosis on or after January 1, 2008 * No exclusions based on primary or secondary treatment modalities * Retrospective group patients must be ≥ 6 months post end of treatment at study entry * For those already at this timepoint, they are now eligible * For those in treatment, or otherwise not yet at this timepoint, they are eligible once at they are ≥ 6 months post end of treatment * Prospective group patients must not have begun treatment * Patients with diminished capacity will not…
Interventions
- ProcedureBiospecimen collection
Collection of tissue and saliva samples
- OtherVision assessment
Undergo vision assessment
- OtherQuestionnaire administration
Complete questionnaires
- OtherQuality of life assessment
Complete questionnaires
- OtherLaboratory Biomarker Analysis
Correlative studies
Locations (11)
- Lurie Children's HospitalChicago, Illinois
- University of Illinois, ChicagoChicago, Illinois
- University of MinnesoaMinneapolis, Minnesota
- Washington School of Medicine at St. LouisSt Louis, Missouri
- Cincinnati Children's Hospital Medical CenterCincinnati, Ohio
- Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania